Toward Functional Carboxylate-Bridged Diiron Protein Mimics: Achieving Stability and Conformational Flexibility Using a Macrocylic Ligand
نویسندگان
چکیده
A dinucleating macrocycle, H2PIM, containing phenoxylimine metal-binding units has been prepared. Reaction of H2PIM with [Fe2(Mes)4] (Mes = 2,4,6-trimethylphenyl) and sterically hindered carboxylic acids, Ph3CCO2H or ArCO2H (2,6-bis(p-tolyl)benzoic acid), afforded complexes [Fe2(PIM)(Ph3CCO2)2] (1) and [Fe2(PIM)(ArCO2)2] (2), respectively. X-ray diffraction studies revealed that these diiron(II) complexes closely mimic the active site structures of the hydroxylase components of bacterial multi-component monooxygenases
منابع مشابه
Evolution of strategies to prepare synthetic mimics of carboxylate-bridged diiron protein active sites.
We present a comprehensive review of research conducted in our laboratory in pursuit of the long-term goal of reproducing the structures and reactivity of carboxylate-bridged diiron centers used in biology to activate dioxygen for the conversion of hydrocarbons to alcohols and related products. This article describes the evolution of strategies devised to achieve these goals and illustrates the...
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